Welcome!
| The Neuropharmacology Core (NPC) enables investigators to use in vitro and in vivo assays to serve as a guide in the isolation and identification of biological-active natural products and to evaluate compounds predicted to have activities in these systems through rational drug design. The Core uses human neuroblastoma cell lines for assessment of neurotoxicity and neuroprotection in response to drug treatment. The in vivo component of the Neuropharmacology Core currently provides the resources and technical support necessary for drug administration in animal models and analysis of many aspects of animal behavior in response to treatment. Zebrafish assays of developmental toxicity and anti-epileptic effects of drugs are available, and include both genetic and pharmacological induced seizures. Our rodent models (mice and rats) include assays of abuse potential, cannabinoid function (temperature, locomotion, pain, and catalepsy), ataxia, anti-nociception, anxiolytic, anti-depressant, allodynia, and post-traumatic stress effects. Additionally, learning and memory as well as muscle strength can be assessed in both mice and rats. Together, we can develop protocols to best suit the needs of investigators when administering novel compounds to our various animal assays. Services: • In vitro o Neuroprotection and EC-50 o Neurotoxicity • In vivo o Hotplate o Tail flick o Acetic acid writhing o Von Frey o Cisplatin induces neuropathy o Complete Freund’s adjuvant o Elevated plus maze o Forced swim test o Tail Suspension o Conditioned place preference o Morris water maze o Barnes maze o Radial arm maze o Y-maze o Open field o Rotarod o Grip strength o Zebrafish seizure and toxicity o Tissue harvest o Tetrad assay |
| Katie Heath | NPC Director | 662.915.2895 | keheath@olemiss.edu |
| Hours | Location | |
|
Monday - Friday 8am - 5pm |
|
| Name | Role | Phone | Location | |
|---|---|---|---|---|
| Katie Heath |
NPC Director
|
(662) 915-2895
|
keheath@olemiss.edu
|
| Service list |
| Name | Description | Price |
|---|---|---|
| Acetic acid writhing - Chemo-Inflammatory Antinociception | Inquire | |
| Barnes Maze - Spatial Learning and Memory | Inquire | |
| Cisplatin Induced Neuropathy - Analgesia in Oncology Settings | Inquire | |
| Complete Freunds Adjuvant - Anti-inflammatory Screening | Inquire | |
| Conditioned Place Preference - Abuse Liability | Inquire | |
| Elevated Plus Maze - Anxiolytic Activity | Inquire | |
| Forced Swim Test - Anti-depressant Activity | Inquire | |
| Grip Strength - Muscle Strength | Inquire | |
| Hotplate - Thermal Antinociception | Inquire | |
| Morris Water Maze - Spatial Learning and Memory | Inquire | |
| Neuroprotection Assay - Screening- % Death | Inquire | |
| Neuroprotection EC-50 Assay - EC-50 Determination | Inquire | |
| Neurotoxicity Assay - EC-50 Determination | Inquire | |
| Open Field - Locomotor Activity | Inquire | |
| Radial Arm Maze - Spatial Learning and Memory, Working Memory | Inquire | |
| Rodent PTSD - Anti-PTSD | Inquire | |
| Rotarod - Ataxia | Inquire | |
| Tail Flick - Thermal Antinociception | Inquire | |
| Tail Suspension - Anti-depressant Activity | Inquire | |
| Tetrad Assay (body temperature, hot plate, tail flick, catalepsy, locomotion) | Inquire | |
| Tissue Harvest | Inquire | |
| von Frey - Allodynia and Hyperalgesia | Inquire | |
| XFe96 Seahorse Analyzer | Inquire | |
| Y-maze - Spatial Learning and Memory, Working Memory | Inquire | |
| Zebrafish PTZ Seizure - Anti-seizure | Inquire | |
| Zebrafish Toxicity - Toxicity | Inquire |
