Pharmacology & Toxicology Core Facilities | Assay Development & Drug Repurposing Core

 

      

Overview of Services

The Department of Pharmacology and Toxicology Core Facilities are multiuser, communal research laboratories that total an approximate 4470 sq. ft. of research space maintained by the department. These facilities are designed to aid and advance the research, in an efficient manner, of individual investigators. The underlying goals of the Core Facilities are to maximize research space, reduce instrumental redundancy, while providing centralized oversight for instrumental maintenance, validity and optimization. The Core Facilities provide these services at cost to the investigator. 

 

Core Equipment is found in one of the designated Core Facility rooms or a Primary Investigator’s laboratory. Core Equipment may be used by departmental and external researchers, once appropriately trained and authorized. The Core Equipment Definition attributes responsibilities on behalf of the Core Facilities, the Department of Pharmacology and Toxicology, and all Core Facility Users. These responsibilities are detailed within each Equipment / Facility SOP and corresponding policy. Equipment / Facility SOPs are issued by the Core Facility Committee and are biannually reviewed and contractually acknowledged by the Department and Facility Users. 

List of Available Cores
  • Assay Development and Drug Repurposing Core (see below)
  • Autoclave Core
  • Cold Room Cores
  • Dark Room Cores
  • Flow Cytometry Core
  • Large Equipment / Freezer Core
  • Microscopy Core
  • Molecular & Biochemistry Core
  • Survival Surgery Core
  • Tissue Culture Core 
  • Large-Format Print Core

 

Overview of Services

The MSU Assay Development and Drug Repurposing Core (ADDRC) facility located in the Department of Pharmacology and Toxicology was created to assist MSU researchers with bridging the drug discovery gap that often exists between their basic research and preclinical drug development. The primary focus of the ADDRC is to aid investigators in developing HTS-compatible assays, to generate preliminary data for grants and funding opportunities, and to screen biological targets with the goal of providing chemical probes to further interrogate a particular biological process or potential leads for drug development.

Equipment and Resources

The ADDRC will be equipped with compound screening libraries on the order of 35,000 compounds, including about 1000 FDA-approved drugs with the aim of identifying new indications for existing clinical compounds or drug repurposing. The facility possess a variety of 96/384-tip liquid handlers, bulk liquid dispensers, and multi-format plate readers with the capacity to address multiple assay methodologies. Faculty also have access to a microscopy-based high-throughput instrument for automated high content imaging and analysis of fixed or live cells. And most recently, the ADDRC facility has acquired a functional drug screening system (FDSS) , a state-of-the-art imaging plate reader for kinetic cell-based assay development and HTS. While the ADDRC is located in the Life Sciences Building (B411), it is a shared resource established to serve faculty across the MSU campus. In addition, the involvement of undergraduate/graduate students and postdoctoral scientists from investigators’ laboratories, who are interested in learning more about drug discovery and the principles of high-throughput screening, is strongly encouraged.

*The ADDRC facility was established through the generous support of the Vice President for Research and Graduate Studies, the Pharmacology and Toxicology Department, CNS, COM, CHM, CVM, and AgBioResearch.

 

Leadership

  

Richard Neubig  M.D., Ph.D.
Chair & Professor
B423 Life Sciences
Email: rneubig@msu.edu
Phone: 517-353-7145
Fax: 517-353-8915

 

Thomas Dexheimer B.S., Ph.D.
Manager of Assay Development and Drug Repurposing Core Facility
Email: dexheim1@msu.edu
Phone: 517-353-7145
Fax: 517-353-8915

 

Heather L. deFeijter-Rupp B.S.
Manager, Core Facilities
Email: rupp@msu.edu
Phone: 517-884-8023
Fax: 517-353-8915

 

Matthew Bernard B.S., Ph.D.
Manager of Flow Cytometry Core Facility
Email: matthew.bernard@ora.msu.edu
Phone: 517-432-7763
Fax: 517-353-8915

 

Location and hours of operation

Hours Location

Staff Hours:
9am-5pm - M-F       

1355 Bogue St. Life Science
East Lansing, MI 48824

Links and Resources

  1. LOCATION ON CAMPUS MAP
  2. CORE FACILITIES WEBSITE
  3. [ etc... ]

Pricing


Search available services: View: by category alphabetically
Flow Cytometry Core Facility (7)
Assay Development (2)
Monthly Equipment Usage (8)
Primary Screening (6)
Screen Follow-up (1)
unclassified (2)

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