ALERT

In Observance of U.S. Holiday, Independence Day, Agilent Cross Lab/ iLab Operations Software Support Help Desk will be closed during U.S. hours on Friday July 3rd, 2020. We will resume regular U.S. support hours on Monday July 6th, 2020. EU and APAC Support will remain open during this time. For urgent matters, please add "Urgent" to the ticket/ email subject or press "1", when prompted, to escalate a call on the iLab Support phone and we will prioritize those requests first.

Pharmacology & Toxicology Core Facilities | Flow Cytometry Core | Assay Development & Drug Repurposing Core

 

      

Return to Research Guidelines for Core Use

https://phmtox.msu.edu/covid-19/ Forms available on our website, along with SOPs for each core.

Please be aware that core occupancy will be reduced for the foreseeable future.  

B409/Autoclave Core-1 person at a time.

B302/402/415/Coldrooms-1 person at a time.

B410/Darkroom Core-1 person at a time.

B407/Tissue Culture Core-1 person at a time.

B300/Tissue Culture Core-3 people at a time (social distancing).

B303/Microscopy Core-1 person at a time.

B446/Molecular and Biochemistry Core-2 people at a time (social distancing) Floor plan available to view at phmtox.msu.edu/facilities/core-facilities.

B400/Freezer Core-1 person at a time.

B303/B409/Large Equipment-1 person at a time.

 

Appropriate PPE (gloves/lab coat/mask) are required for each core. 

You are required to clean the area before leaving the core.

Please direct questions or concerns to core manager in B442 or B400.

Thank you for helping keep everyone safe!

 

 

Overview of Services

The Department of Pharmacology and Toxicology Core Facilities are multiuser, communal research laboratories that total an approximate 4470 sq. ft. of research space maintained by the department. These facilities are designed to aid and advance the research, in an efficient manner, of individual investigators. The underlying goals of the Core Facilities are to maximize research space, reduce instrumental redundancy, while providing centralized oversight for instrumental maintenance, validity and optimization. The Core Facilities provide these services at cost to the investigator. 

Core Equipment is found in one of the designated Core Facility rooms (listed below with PHM/TOX as the desigantion) or a Primary Investigator’s laboratory. Core Equipment may be used by departmental and external researchers, once appropriately trained and authorized. The Core Equipment Definition attributes responsibilities on behalf of the Core Facilities, the Department of Pharmacology and Toxicology, and all Core Facility Users. These responsibilities are detailed within each Equipment / Facility SOP and corresponding policy. Equipment / Facility SOPs are issued by the Core Facility Committee and are biannually reviewed and contractually acknowledged by the Department and Facility Users. 

List of Available Cores
  • Assay Development and Drug Repurposing Core (see below)
  • MSU Flow Cytometry Core (see below)
  • PHM/TOX Autoclave Core
  • PHM/TOX Cold Room Cores
  • PHM/TOX Dark Room Core
  • PHM/TOX Large Equipment
  • PHM/TOX Freezer Core
  • PHM/TOX Microscopy Core
  • PHM/TOX Molecular & Biochemistry Core
  • PHM/TOX Survival Surgery Core
  • PHM/TOX Tissue Culture Cores 
  • PHM/TOX Large-Format Print Core

 

 

ADDRC Services

The MSU Assay Development and Drug Repurposing Core (ADDRC) facility located in the Department of Pharmacology and Toxicology was created to assist MSU researchers with bridging the drug discovery gap that often exists between their basic research and preclinical drug development. The primary focus of the ADDRC is to aid investigators in developing HTS-compatible assays, to generate preliminary data for grants and funding opportunities, and to screen biological targets with the goal of providing chemical probes to further interrogate a particular biological process or potential leads for drug development.

ADDRC Equipment and Resources

The ADDRC will be equipped with compound screening libraries on the order of 35,000 compounds, including about 1000 FDA-approved drugs with the aim of identifying new indications for existing clinical compounds or drug repurposing. The facility possess a variety of 96/384-tip liquid handlers, bulk liquid dispensers, and multi-format plate readers with the capacity to address multiple assay methodologies. Faculty also have access to a microscopy-based high-throughput instrument for automated high content imaging and analysis of fixed or live cells. And most recently, the ADDRC facility has acquired a functional drug screening system (FDSS) , a state-of-the-art imaging plate reader for kinetic cell-based assay development and HTS. While the ADDRC is located in the Life Sciences Building (B411), it is a shared resource established to serve faculty across the MSU campus. In addition, the involvement of undergraduate/graduate students and postdoctoral scientists from investigators’ laboratories, who are interested in learning more about drug discovery and the principles of high-throughput screening, is strongly encouraged.

*The ADDRC facility was established through the generous support of the Vice President for Research and Graduate Studies, the Pharmacology and Toxicology Department, CNS, COM, CHM, CVM, and AgBioResearch.

 

 

MSU Flow Cytometry Core Services

The mission of the MSU Flow Cytometry Core Facility is to provide investigators with cell sorting services and access to cutting-edge analytical flow cytometry instrumentation, as well as training and experimental consultation. We are graciously supported by the MSU Office of the Senior Vice President for Research & Innovation (VPRI), the College of Human Medicine (CHM), and the College of Osteopathic Medicine (COM).

MSU Flow Cytometry Core Equipment and Resources

The MSU South Campus Flow Cytometry Core hub is located on the second floor of the IQ Bioengineering Building (Rm 2521 and 2522). Instrumentation available in IQ include a BD FACSAria IIu cell sorter, a Cytek Aurora spectral cytometer (5 laser), a BD Accuri C6, and a Luminex 200. The MSU North Campus Flow Cytometry Core hub is located on the fifth floor of the Biophysical Science Building (BPS, Rm 5115). Instrumentation available in BPS include a BD Influx cell sorter and a BD LSR II benchtop analyzer. Laboratory space for the South Campus hub is approximately 300 sq. ft. and approximately 263 sq. ft. for the North Campus hub. The MSU Flow Cytometry Core is directed by Dr. Matthew Bernard who both provides professional oversight of the Core Facility and assay development expertise, as well as technical support and guidance for general education in flow cytometry principles. The Core is managed by Dr. Daniel Vocelle, who oversees instrument and data analysis training, assay/application development, as well as technical support and guidance for general education in flow cytometry principles. 

 

Leadership

Richard Neubig  M.D., Ph.D.
Chair & Professor
B423 Life Sciences
Email: rneubig@msu.edu
Phone: 517-353-7145
Fax: 517-353-8915

 

Thomas Dexheimer B.S., Ph.D.
Manager of Assay Development and Drug Repurposing Core Facility
Email: dexheim1@msu.edu
Phone: 517-353-7145
Fax: 517-353-8915

 

Heather L. deFeijter-Rupp B.S.
Manager, PHM/TOX Core Facilities
Email: rupp@msu.edu
Phone: 517-884-8023
Fax: 517-353-8915

 

Matthew Bernard B.S., Ph.D.
Director, MSU Flow Cytometry Core Facility
Email: mbernard@msu.edu
Phone: 517-355-4076
Fax: 517-353-8915

 

Daniel Vocelle B.S., Ph.D.
Manager, MSU Flow Cytometry Core Facility
Email: vocelled@msu.edu
Phone: 517-355-1536
Fax: 517-353-8915

 

Location and hours of operation

Pharmacology & Toxicology Core Facilities

Hours Location

Staff Hours:
8am-5pm - M-F   

Special hours per request   

1355 Bogue St. Life Science
East Lansing, MI 48824

 

ADDRC

Hours Location

Staff Hours:
9am-5pm - M-F       

1355 Bogue St. Life Science
East Lansing, MI 48824

 

MSU Flow Cytometry Core

IQ/Bioengineering Facility

Hours Location

Staff Hours:
9am-5pm - M-F       

775 Woodlot Dr, IQ/Bioengineering Facility
East Lansing, MI 48824

BPS

Hours Location

Staff Hours:
9am-5pm - M-F       

567 Wilson Rd, BPS
East Lansing, MI 48824

 

 

Links and Resources

  1. Pharmacology & Toxicology Core Facilities
  2. MSU Flow Cytometry Core
  3. ADDRC

Pricing


Search available services: View: by category alphabetically
Flow Cytometry Core Facility (2)
Assay Development (2)
Monthly Equipment Usage (8)
Primary Screening (6)
Screen Follow-up (1)
unclassified (2)

Map