Welcome!
ALERT ATTENTION ⚠️
In observance of the holiday, Juneteenth, Agilent CrossLab/iLab Operations Software Support Help Desk will be closed during U.S. hours on Thursday, June 19th, 2025. We will resume regular U.S. support hours on Friday, June 20th, 2025. EU and APAC Support will remain open during this time. For urgent matters, please add "Urgent" to the ticket/email subject or press "1" when prompted to escalate a call on the iLab Support phone, and we will prioritize those requests first.
The TKAP has been in operation at COH since the early 1990s, and is focussed on the production of genetically-modified animal models for basic and translational research. The TKAP produces transgenic mice by pronuclear microinjection, or by sub-zonal injection of pseudotyped self-inactivating lentiviral vectors. The TKAP generates mouse models carrying targeted gene inactivation (knock-out), or specific modifications of the nucleotide sequence of genes (knock-in) using mouse embronic stem cells (mESC). The TKAP also performs genome engineering with sequence-specific nucleases (TALENs & CRISPR/Cas9) in mESC, or directly in mouse zygotes. In addition the TKAP cryopreserves mouse embryos and gametes, and rederives mouse strains by in vitro fertilization and embryo transfer.
| Name | Role | Phone | Location | |
|---|---|---|---|---|
| Walter Tsark |
Director
|
84095
|
wtsark@coh.org
|
655 Huntington Dr
|
