Cardiovascular Physiology Core

Overview of Services

 

The Cardiovascular Physiology Core is designed to provide preclinical research expertise to our clients - academic, non-profit and corporate-based, who are interested in using proven disease models from zebrafish to rodents to assess therapeutics or establish novel models using small animals and fish. We have the capacity to facilitate research and training, from in vivo to ex vivo to in vitro models, using primary cells and cell lines as well as can engage in molecular discovery using animal models. Although we are primarily focused on cardiovascular disease area we have recently expanded to whole body imaging via a preclinical ultrasound technology platform. We offer extensive post-acquisition data analysis whereby researchers can quantify the obtained data in a robust and facile way. We can meet a variety of preclinical translational needs of our research community and have engaged nationally and internationally, with an array of successful collaborations that have led to more than 500 publications, grants, and also led to some clinical trial testing (small molecule and gene-therapy).  We offer both full-service and limited service options and are always open to new collaborations.

 Our services include but are not limited to: 

  • Echocardiography and High-Frequency Ultrasound Imaging of multiple organs (Vevo 3100)
  • Training + Assisted Service
  • Unassisted Service
  • Systemic in vivo Imaging and post-imaging Data Analysis (assisted, training or unassisted)
  • In vivo modeling of cardiac disease (multiple models; eg. vasculopathy, cardiac & muscle diseases, renal pathologies, cancer, neonatology, abdominal and inflammatory conditions)
  • Phenotypic screening using rodent and fish models
  • Surgery (includes, but not limited to, the following procedures)(mouse and rat)
    • Myocardial infarction model 
    • Ischemic reperfusion model
    • Banding model (TAC, PAC, AAC)
    • Pulmonary Hypertension model (rats and mice)
    • Injections which could be intramyocardial or parenteral (rats, mice and fish)
  • Blood Pressure Measurement (invasive, cath-based and noninvasive)
  • Langendorff (ex vivo)
  • PV Loop relationships assessment and associated data analysis (ADI Instruments platform)
  • Isolated Heart function assessment capability (includes injections, tissue harvest, sample collection)
  • Cardiomyocyte (CM) and fibroblast (CF) Isolation (rats and mice, adult and neonatal)
  • Animal procurement, housing, transfer, import/export
  • Post-surgery monitoring (required for in vivo longitudinal survival studies)

We can work off-site for surgery and imaging needs.

 

 

Core Leadership

Ronglih Liao, Ph.D. | Director BWH Cardiovascular Physiology Core

rliao@rics.bwh.harvard.edu 

Sudeshna Fisch, Ph.D. | Associate Director BWH Cardiovascular Physiology Core 

    sfisch@bwh.harvard.edu

 

 

Location 

 
We are located in the NRB building, 4th floor in Room 435F
 
BWH, NRB 0435F
77 Avenue Louis Pasteur
Boston, MA 02115

Contact: Phone: 617 525 4983 OR 781 956 2761

 BWH Cardiovascular Physiology Core Website

 

Contacts

Name Role Phone Email Location
Sudeshna Fisch
Associate Director
 
(617) 525-4983
 
sfisch@bwh.harvard.edu
 
NRB431
 
Alex Loscalzo
Core Contact
 
(617) 525-4862
 
aloscalzo@partners.org
 
NRB431
 
Souen Ngoy
Surgeon
 
(617) 525 4864
 
sngoy@rics.bwh.harvard.edu
 
NRB431