Electron Microscopy and Histology Core Facility

Overview of Services 

The Electron Microscopy & Histology (EM&H) Core offers a wide range of high-quality services to support your research—from standard histology to advanced transmission electron microscopy. Core staff provides assistance in using the instruments, training to enable independent use, and consultation to address individual research needs.

Services We Offer

General Histology

• Full-service support and training
• Tissue fixation, processing, embedding, and sectioning (FFPE and frozen)
• H&E staining
• Embedding and sectioning of cell pellets and organoids (EM, FFPE, frozen)

Specialized Sectioning for Spatial Biology, Proteomics & Multiplexing Platforms

• Sectioning for platforms such as:
  Lunaphore COMET, Bruker CellScape, MALDI, 10x Visium, CosMx, and more
• (User must provide specialized slides)

Tissue Microarray (TMA) Construction

• Custom TMA construction from paraffin blocks
• Sectioning and staining for IHC, IF, and histological stains

Transmission Electron Microscopy (TEM)

• Full service and user training
• Resin embedding, ultrathin sectioning, and negative staining
• Immunogold labeling for TEM

IHC, IF, and ICC Staining

• Training and staining services (user provides primary antibodies)
• Protocols for paraffin/frozen sections and cultured cells
• Whole-mount and multi-antibody labeling

Histological Stains Offered

• H&E
• Oil Red O
• Wright-Giemsa
• Nuclear Fast Red
• Methyl Green
• Toluidine Blue
• Alcian Blue
• Masson’s Trichrome
• Mallory’s Trichrome (AFOG)
• Other stains by request

Animal Dissection Services

• Available for mouse, rat, and higher species

Facility Acknowledgement

If you’ve received support or services from the EM&H Core, we kindly request that you acknowledge us in your publications or presentations. This recognition helps demonstrate the value of our Core and supports continued institutional investment.

Acknowledgment Guidelines

• For general EM&H services:
  “Electron Microscopy & Histology services were provided by the Weill Cornell Medicine Microscopy & Image Analysis Core.”
• If your work includes TEM imaging:
  “TEM imaging was performed using an instrument purchased with funds from an NIH Shared Instrumentation Grant (S10RR027699) for Shared Resources.”

Please let us know about any acknowledgments and publications, especially if they include images or data generated using Core instrumentation.

Submit publication or grant information here: https://weillcornellmicroscopy.org/submit-publicationgrant-info

Getting Started

• WCMC Users:  

• Non-WCMC Users:  
  1. Got o https://wcmc.corefacilities.org/account/login#
  2. Click on Register on upper right corner and select Register for an iLab account
  3. A new window opens. This starts the registration process for a new account. You will need to fill out several pages of forms, starting with your basic contact information. This information should include your full email address, institution ect.

Contacts

Dena Almeida, Senior Core Director Email: dalmeid@med.cornell.edu

Location and Hours of Operation

Links and Resources

1. https://research.weill.cornell.edu/core-facilities-wcm
2. https://weillcornellmicroscopy.org/

Contacts

Available Equipment and Resources